you want to know
1-Age and sex
Here is a guide for the risk factors for AlZheimer’s. The risk of AlZheimer’d doubles every five years after the age of 65. The incidence increases to one third of people aging 85 years or more. In fact, AlZheimer’s is more prevalent in women more than men with more than 60% of AlZheimer’s disease patients are women. Women show worse disease pathology and accelerated brain degeneration than men (1)
2Diabetes mellitus type II and obesity.
Obesity, Diabetes mellitus type II, hypertension and/or lifestyle habits (e.g. smoking, physical activity, diet, mental and social activity) are modifiable risk factors for AlZheimer disease.
Diabetes can increase the risk directly by accumulation amyloid beta peptides in the brain tissues. diabetes also is a prominent risk factors of brain strokes which in turn predisposes to Alzheimer. (2)
3-Mid-life Hypertension
Hypertension is capable of causing changes in the brain vessels walls which can lead to decrease blood flow and brain ischemia contributing to trigger the development of AD (3). In addition, hypertension also is a prominent risk factors of brain strokes which in turn predisposes to Alzheimer
4-Family History.
Family History of Alzheimer’s diseases increases the risk of early-onset (young-onset) Alzheimer. Early onset Alzheimer starts before 65 years, in the 30s or 40s. (4)
5-Smoking
A prominent modifiable risk factor: smoking increases inflammatory markers and oxidative stress on the cellular level. Additionally, smoking also is a prominent risk factors of brain strokes which in turn predisposes to Alzheimer.
6-Physical & cognitive Inactivity
Physical activity and exercise as well as sports promote brain health by several mechanisms including increase blood supply to the brain and reduction of amyloid chains deposition in the brain tissues as well as reduction of inflammatory markers. In fact, participation in exercise program has been shown to significantly improve cognitive function in healthy older people
7-Depression
Depression is both a risk factor and a consequence. About half of patients with AlZheimer suffer from depression. Adequate treatment of treatment can lead to better outcome.
8-High cholesterol levels
A key step in the treatment is early diagnosis. Early diagnosis and treatment help to slow the disease progression.
9-History of head trauma
With increasing aging population, head trauma unfortunately is expected to continue to rise. Brain injury accelerates amyloid peptides production and accumulation in the brain tissues.
10-Genetic factors and risk factora for alzheimer’s
The presence of APOE4 allele genes; similarly, to family history increases the risk of early-onset Alzheimer. In fact, 70% of the risk of developing AlZheimer’s can be attributed to genetics